Ketogenic Diet and Its Applications in Ehlers-Danlos Syndrome

Ehlers-Danlos syndrome (EDS) encompasses a group of hereditary connective tissue disorders characterized by abnormal collagen structure and function. Common comorbid conditions include mast cell activation syndrome, dysautonomia, and cardiovascular abnormalities. This paper examines potential benefits of the ketogenic diet (KD) for individuals living with EDS. KD, a low-carbohydrate and high-fat diet, induces ketosis with production of ketones such as acetoacetate and beta-hydroxybutyrate. Given the prevalence of nutritional deficiencies and gastrointestinal dysfunctions in patients with EDS, especially in vitamins C, D, zinc, and copper, KD’s impact on these deficiencies and overall health is investigated. KD’s energy-boosting abilities, anti-inflammatory effects, and potential for neurologic benefits are highlighted. Although side effects of KD may occur, its integration with comprehensive management strategies such as vitamin supplementation, physical therapy, and pharmacotherapy, may offer significant improvements for quality of life in patients with EDS. Further research is necessary to elucidate KD’s long-term efficacy and mechanism in this patient population.